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How can a cell maintain itself as a living being? Living cells, shaped by billions of years of evolution, have developed many ways to adapt to their environment, e.g. by regulation of gene expression. But the rules of physics and chemistry enforce certain boundaries on what cells can achieve and how they can allocate their own resources. Our goal is to uncover some of these governing principles. Shaped by evolution, cells "do certain things right", and computational models of cells often assume that this "doing something right" can be described by evoking optimality principles.
In our open textbook - to which anyone can contribute - we intend to give an overview of established approaches to "cellular economics", from descriptions of simple metabolic systems to cell growth, variability, and dynamic behaviour. For more information about our book project, please see our website for (actual and potential) authors and this poster.
To join us in writing this free and open textbook, please get in touch!
Here you can find our current manuscript (which is still a "preview version"). We plan to release updated versions every 3 months.
Entire book (pdf)
Authors and financial support
Please see our list of authors and supporting institutions.
Some chapters were presented as lectures at the 2022 Summer school Economic Principles in Cell Bioloy at LPI Paris. Below you find lecture slides. Numbers refer to chapter numbers. Lectures without a number will be featured in future editions of the book.
Computer code and tutorials
Here you can find instructional jupyter notebooks
Here you can find python code accompanying the book
The book is published under the Creative Commons license CC BY-SA, which allows you to share and adapt (also for commercial purposes) if you give appropriate credit, provide a link to the license, and indicate if changes were made. If you remix, transform, or build upon the material, you must distribute your contributions under the same license CC BY-SA.
Anybody is welcome to contribute to our book! If you're interested, please see our project page principlescellphysiology.org/book.html